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Neurotoxicity

Cognitive Dysfunction

Peripheral Neuropathy

Cognitive Dysfunction

Cancer-related Cognitive Dysfunction (CancerSymptoms.org)
Provides basic information on cancer-related cognitive problems, which may include memory loss, distractibility, difficulty in performing multiple tasks, and trouble with arithmetic and language skills. Discusses the causes and symptoms of cancer-related cognitive dysfunction, as well as treatment strategies, including pharmacologic therapy, rehabilitation, support groups and behavioral approaches. [undated]

Multidisciplinary Team Helps Patients with Cancer Overcome Cognitive Problems (MD Anderson)
Discusses the experience at MD Anderson of a multidisciplinary approach to cognitive problems that may occur during and after cancer treatment. [12/01]

Neurocognitive Dysfunction in Cancer Patients (cancernetwork.com)
v. 14, no.1 ONCOLOGY (January 2000)
Discusses cancer-related impairments of neurocognitive function (including memory loss, distractibility, difficulty in performing multiple tasks, among others) and their causes. Sections include: effects of cancer, effects of treatment, coexisting neurologic conditions, functional and psychiatric disorders, metabolic disturbances, evaluating cognitive dysfunction, and intervention strategies. [1/00]

Memory Problems Following Chemotherapy (WebMD)
Summarizes a study published in the 1/15/02 issue of the Journal of Clinical Oncology that found cognitive (thinking and memory) effects that persist for years, but that the benefits of chemotherapy outweigh the potential risks to cognitive functioning for most people. [1/02]

Chemotherapy and Cognitive Function: Maybe It is All in Their Heads?
(Medscape)
Discusses 2 studies presented at the 37th Annual ASCO meeting that examined the effect of chemotherapy and hormonal therapy on brain function. Although research in this area is in its infancy, preliminary results suggest that the cognitive effects are real. Studies are ongoing.[5/01]

Prophylactic Cranial Irradiation in Small-Cell Lung Cancer (The Oncologist)
5, no.4 The Oncologist (August 2000): 293-298
Excellent comprehensive review of the literature on prophylactic cranial irradiation in SCLC patients. See also the commentary by Andrew T. Turrisi: "PCI in SCLC: Is It Still Controversial or Is It a No-Brainer?" in the same issue of The Oncologist. Includes an extended discussion of the potential, nature and likelihood of cognitive side effects from PCI. [8/00]



Peripheral Neuropathy

Facing the Challenge (Cure)
by Debra Wood, RN
v.3, no.3 CURE (Fall 2004): 58-62
Patient article on peripheral neuropathy and cancer treatment: how and why it happens, which drugs may cause peripheral neuropathy; signs and symptoms; which patients are at risk; possible treatments; and how to manage neuropathy, including a list of safety tips. [10/04]

Managing Symptoms: Peripheral Neuropathy (Nerve Damage) (OncoLink)
Addresses the following questions: what is peripheral neuropathy? what causes peripheral neuropathy and how long will it last? what are the common symptoms of peripheral neuropathy? Offers advice on things you can do to manage peripheral neuropathy. Aimed at patients. [2/02]

CANCER-NEUROPATHY (Association of Cancer Online Resources)
Online discussion group for cancer patients dealing with neuropathy induced by cancer and its treatments.

Peripheral Neuropathy (MayoClinic.com)
Overview of peripheral neuropathy, its signs and symptoms, causes, complications, and treatment. Although this article addresses peripheral neuropathy resulting from various causes other than cancer and chemotherapy, the treatment section includes useful information on medications, therapies, self-care and coping strategies. [11/05]

Tips for Dealing with Neuropathy (Conversations: The International Newsletter for Those Fighting Ovarian Cancer)
Patient-created guide to dealing with peripheral neuropathy caused by chemotherapy. Provides information on locating specialists who treat neuropathy, discusses the use of Amifostine (Ethyol) to prevent neuropathy, and offers information on treatments and coping strategies. Suggests additional resources for patients with peripheral neuropathy. [3/04]

Neuroprotective Effect of Vitamin E Supplementation in Patients Treated with Cisplatin Chemotherapy (Journal of Clinical Oncology)
Abstract of a study published in the March 1, 2003 issue of the Journal of Clinical Oncology to evaluate the neuroprotective effect of antioxidant supplementation with Vitamin E in patients treated with cisplatin chemotherapy. Concludes that Vitamin E supplementation of patients receiving cisplatin chemotherapy decreases the incidence and severity of peripheral neurotoxicity. [3/03]


 

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Last modified: 30-Nov-2007
Karen Parles, MLS Editor