General Information
Bone
Metastasis (bonetumor.org)
Offers a basic introduction to bone metastasis, including a section on
bone metastasis
from lung cancer. [1996]
Imaging of Bone Metastasis
Evaluation
of Bone Metastases in Lung Cancer (H.Lee Moffitt Cancer
Center)
by Poonam Malhotra, MD and Claudia G. Berman, MD
v.9, n.3 Cancer Control Journal (May/June 2002): 254-55
Case study illustrating how FDG-PET scans offer advantages over bone scans
for detecting bone metastases from lung cancer. Suggests that FDG-PET
can be useful in determining the presence of active metastatic disease
following treatment and is useful in monitoring response to therapy. (Be
sure to click on the "Discussion" button at the bottom of the page.) [2002]
Specific Therapies
Bisphosphonates
Zometa
(Lung Cancer Online)
Provides links to information on Zometa (zoledronic acid), a bisphosphonate
used to treat bone metastases from lung cancer.
Radiation Therapy
Single-
vs. Multiple-fraction Radiotherapy in Patients with Painful Bone Metastases:
Cost-Utility Analysis Based on a Randomized Trial (PubMed)
Study published in the 2/5/03 issue of the Journal of the National
Cancer Institute found that single-fraction radiotherapy provides equal
palliation and quality-of-life when compared to multiple-fraction radiotherapy
with no differences found in life expectancy. [2/03]
Radiofrequency Ablation (RFA)
Radiofrequency Heat Ablation and Vertebroplasty in
the Treatment of Neoplastic Vertebral Body Fractures (PubMed)
Abstract of a study to assess the effectiveness and safety of radiofrequency
heat ablation (RFA) and vertebroplasty in the treatment of neoplastic
vertebral body fractures. Concludes that the association of RFA and vertebroplasty
is an effective, simple and safe treatment of vertebral collapse consequent
to metastases. [9/04]
Radiofrequency
Ablation Effective for Pain Associated with Osteolytic Metastatic Lesions
(Medscape)
Reports on a multicenter study presented at the 2002 Radiological
Society of North America (RSNA) annual meeting that demonstrated dramatic
reductions in pain and improved quality of life in patients receiving
radiofrequency ablation (RFA) for treatment of osteolytic metastatic lesions.
Aimed at physicians. Registration required for free access to Medscape.
[12/02]
Radiopharmaceuticals
Surgical Strategies, including Vertebroplasty
Pain
from Bone Metastasis: Surgical Strategies (MD Anderson
Cancer Center)
Discusses surgical options to relieve pain from bone metastasis.
[4/01]
International
Conference on Bone Metastases (ICBM): Cement Filler Prevents Bone Metastases
(Doctor's Guide)
Study results reported at ICBM (June 2000) found that advanced cancer
patients with bony vertebral metastases may have prolonged pain relief
and delayed metastatic-tumor growth when the bony lesions are filled hot
plastic cement in a procedure known as vertebroplasty or cementoplasty.
The procedure can be done in conjunction with chemotherapy or radiotherapy.
[6/00]
Vertebroplasty
- Recent MEDLINE Abstracts (PubMed)
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