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Treatment of Bone Metastases

General Information

Imaging of Bone Metastases

Specific Therapies
bisphosphonates • radiation therapy • radiofrequency ablation (rfa) • radiopharmaceuticals • surgical strategies

General Information

Bone Metastasis (bonetumor.org)
Offers a basic introduction to bone metastasis, including a section on bone metastasis from lung cancer. [1996]



Imaging of Bone Metastasis

Evaluation of Bone Metastases in Lung Cancer (H.Lee Moffitt Cancer Center)
by Poonam Malhotra, MD and Claudia G. Berman, MD
v.9, n.3 Cancer Control Journal (May/June 2002): 254-55
Case study illustrating how FDG-PET scans offer advantages over bone scans for detecting bone metastases from lung cancer. Suggests that FDG-PET can be useful in determining the presence of active metastatic disease following treatment and is useful in monitoring response to therapy. (Be sure to click on the "Discussion" button at the bottom of the page.) [2002]



Specific Therapies

Bisphosphonates

Zometa (Lung Cancer Online)
Provides links to information on Zometa (zoledronic acid), a bisphosphonate used to treat bone metastases from lung cancer.

Radiation Therapy

Single- vs. Multiple-fraction Radiotherapy in Patients with Painful Bone Metastases: Cost-Utility Analysis Based on a Randomized Trial (PubMed)
Study published in the 2/5/03 issue of the Journal of the National Cancer Institute found that single-fraction radiotherapy provides equal palliation and quality-of-life when compared to multiple-fraction radiotherapy with no differences found in life expectancy. [2/03]

Radiofrequency Ablation (RFA)

Radiofrequency Heat Ablation and Vertebroplasty in the Treatment of Neoplastic Vertebral Body Fractures (PubMed)
Abstract of a study to assess the effectiveness and safety of radiofrequency heat ablation (RFA) and vertebroplasty in the treatment of neoplastic vertebral body fractures. Concludes that the association of RFA and vertebroplasty is an effective, simple and safe treatment of vertebral collapse consequent to metastases. [9/04]

Radiofrequency Ablation Effective for Pain Associated with Osteolytic Metastatic Lesions (Medscape)
Reports on a multicenter study presented at the 2002 Radiological Society of North America (RSNA) annual meeting that demonstrated dramatic reductions in pain and improved quality of life in patients receiving radiofrequency ablation (RFA) for treatment of osteolytic metastatic lesions. Aimed at physicians. Registration required for free access to Medscape. [12/02]

Radiopharmaceuticals

Surgical Strategies, including Vertebroplasty

Pain from Bone Metastasis: Surgical Strategies (MD Anderson Cancer Center)
Discusses surgical options to relieve pain from bone metastasis. [4/01]

International Conference on Bone Metastases (ICBM): Cement Filler Prevents Bone Metastases (Doctor's Guide)
Study results reported at ICBM (June 2000) found that advanced cancer patients with bony vertebral metastases may have prolonged pain relief and delayed metastatic-tumor growth when the bony lesions are filled hot plastic cement in a procedure known as vertebroplasty or cementoplasty. The procedure can be done in conjunction with chemotherapy or radiotherapy. [6/00]

Vertebroplasty - Recent MEDLINE Abstracts (PubMed)


 

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Last modified: 27-Apr-2011
Karen Parles, MLS Editor