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Treatment of Brain Metastases


Specific Therapies
chemotherapy • radiation therapy • stereotactic radiosurgery • molecular-targeted therapy

Clinical Trials for Brain Metastasis

Complications of Brain Metastasis


Understanding Brain Metastases (ALCASE)
Comprehensive guide for patients and caregivers intended to provide a basic understanding of brain metastases and their treatment. Topics covered include: what are brain metastases? what are the typical symptoms? how are brain metastases diagnosed? what are the treatment options? how might brain metastases affect me? how can patients and loved ones cope emotionally? where can I get more information? [2003]

Management of Brain Metastases (
by Patrick Y. Wen, MD and Jay S. Loeffler, MD
13, no.7 ONCOLOGY (July 1999)
Comprehensive article on brain metastases includes clinical manifestations, diagnosis, symptomatic therapy, definitive treatment, and prognosis. Registration required for free access to [7/99]

Brain Metastases - Recent MEDLINE Abstracts (PubMed)

Specific Therapies


Temozolomide (Temodar) (Lung Cancer Online)

Triple Therapy with Vinorelbine, Gemcitabine, and Carboplatin Demonstrates Efficacy Against Brain Metastases from NSCLC (Doctor's Guide)
Reports on a 2002 ASCO study that showed a combination of vinorelbine, gemcitabine, and carboplatin is active as primary chemotherapy against brain metastases from NSCLC. [5/02]

Radiation Therapy - Whole Brain

Whole Brain Radiation Therapy With or Without Stereotactic Radiosurgery Boost For Patients with One to Three Brain Metastases: Results of a Phase III Randomized Trial (PubMed)
Abstract of a study published in the May 2004 issue of The Lancet. Study results suggest that WBRT and stereotactic radiosurgery should be standard treatment for patients with a single unresectable brain metastasis and considered for patients with two or three brain metastases. [5/04]

Radiation Therapy - Enhancers/Sensitizers

RSR13 (efaproxiral/Efaproxiral) Information (Lung Cancer Online)

Xcytrin (motexafin gadolinium) & WBRT - Recent MEDLINE Abstracts

Stereotactic Radiosurgery

International Radiosurgery Support Association
Educational organization dedicated to providing information on stereotactic and other specialized radiation treatments. Resources include a description of a typical treatment day, frequently asked questions about radiosurgery, a list of treatment centers and an IRSA newsletter. Of particular interest is the stereotactic radiosurgery overview, which provides general information on stereotactic radiosurgery as well as discussion of particular types such as Gamma Knife and CyberKnife, among others.

Gamma Knife Surgery In the Management of Brain Metastases from Lung Carcinoma (PubMed)
Retrospective study published in the May 2004 issue of the Journal of Neurosurgery that analyzed the results of stereotactic radiosurgery performed using a gamma knife in the treatment of 44 consecutive patients with brain metastases from lung carcinoma. The study concluded that gamma knife surgery significantly reduced the incidence of mortality from brain disease by effectively accomplishing local tumor control in patients with metastatic lung cancer. Local control and freedom from new brain metastases is not influenced by prior external-beam radiotherapy. [5/04]

Radiosurgery for NSCLC Metastatic to the Brain: Long Term Outcomes and Prognostic Factors (Journal of Neurosurgery)
by Jason P. Sheehan, MD, et al.
v.97, no. 6 Journal of Neurosurgery (December 2002)
Examines the efficacy of gamma knife radiosurgery for treating metastases to the brain from NSCLC and evaluates factors affecting long-term survival. Concludes that gamma knife radiosurgery for NSCLC metastases to the brain can enhance patient survival and facilitate local brain tumor control. [12/02]

Stereotactic Radiosurgery - Recent MEDLINE Abstracts (PubMed)

Molecular-targeted Therapy

Iressa & Brain Metastases - Recent MEDLINE Abstracts (PubMed)

Clinical Trials for Brain Metastasis

Brain Metastasis Clinical Trials (

Brain Tumor Treatments - Metastatic Brain Tumors (Musella Foundation)
Listing of clinical trials for metastatic brain tumors.

Complications of Brain Metastasis

THE DRUG - A Steroid Tale (CancerLynx)
Personal account by John Fetto of his wife's experience with Decadron after her lung cancer progressed to her brain. [9/01]


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Last modified: 01-May-2011
Karen Parles, MLS Editor