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NSCLC Treatment - Chemotherapy

Overview of Clinical Research - Chemotherapy & NSCLC
Common NSCLC Drugs & Regimens
clinical research & side effects
Topics & Issues in NSCLC Chemotherapy
chemotherapy vs. best supportive care • duration of chemotherapy • post-surgical (adjuvant) chemotherapy • platinum vs. non-platinum regimens • chemotherapy regimens: how many drugs?
Chemotherapy - What to Expect & Things to Know

Overview of Clinical Research

First-line Chemotherapy Options for Patients with Advanced NSCLC (Medscape)
by Konstantin Dragnev, MD and James Rigas, MD
This article examines the first-line chemotherapy options for patients with advanced NSCLC and reviews the major trials supporting the use of platinum-based regimens. Aimed at physicians. Registration required for free access to Medscape. [2/05]

Chemotherapy & NSCLC Review Articles - Recent MEDLINE Abstracts (PubMed)

Taxane-Platinum Combinations in Advanced NSCLC: A Review (The Oncologist)
by James R. Rigas, MD
v.9 (suppl 2) The Oncologist (June 2004): 16-23
Reviews the use of taxane chemotherapy in the treatment of NSCLC. Identifies key findings from the four large randomized trials assessing platinum-taxane combinations in advanced NSCLC, including efficacy, side effect and quality of life results. Aimed at physicians. [6/04]

Is There a Preferred Combination Chemotherapy Regimen for Metastatic NSCLC? (The Oncologist)
by David S. Ettinger, MD
v.7, no.3 The Oncologist (June 2002): 226-233
Discusses the new chemotherapy agents (paclitaxel, docetaxel, gemcitabine, vinorelbine, irinotecan, and topotecan) used for treatment of advanced NSCLC. Notes that these agents have been combined with cisplatin, carboplatin and nonplatinum drugs to produce median survival times of 8-10 months and 1 and 2 year survival rates of 35-40% and 10-15% respectively. Based on this review, there is not a preferred combination chemotherapy to treat advanced NSCLC patients; however, there are a number of different regimens from which to choose. Aimed at physicians. [6/02]

Chemotherapy in Advanced NSCLC (Medscape)
Summary, by Tracey L. Evans, MD, of results of chemotherapy trials for NSCLC presented at ASCO 2001. Aimed at physicians. Registration required for free access to Medscape. [5/01]

Common NSCLC Drugs & Regimens

Camptosar (irinotecan; CPT-11) (Lung Cancer Online)

Camptothecin (Lung Cancer Online)

Carboplatin (Paraplatin) (Lung Cancer Online)

Cisplatin (Platinol) (Lung Cancer Online)

Epirubicin (Lung Cancer Online)

Gemzar (gemcitabine) (Lung Cancer Online)

Navelbine (vinorelbine) ( Lung Cancer Online)

Oxaliplatin (Lung Cancer Online)

Taxol (paclitaxel) (Lung Cancer Online)

Taxotere (docetaxel) (Lung Cancer Online)


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Last modified: 27-Apr-2011
Karen Parles, MLS Editor