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Treatment of the Elderly NSCLC Patient

General Information - Overview
Chemotherapy & the Elderly NSCLC Patient
Radiation & the Elderly NSCLC Patient
Surgery & the Elderly NSCLC Patient
Case Studies - Elderly NSCLC Patients

General Information - Overview

NSCLC in the Elderly (The Oncologist)
by Paris Makrantonakis, et al.
v.9, no.5 The Oncologist (Sept. 2004): 556-560
Review article summarizing recent research regarding treatment of elderly patients with NSCLC. Published studies have provided strong evidence of improved progression-free survival, overall survival and quality of life in elderly patients with appropriately treated NSCLC. In deciding treatment strategies for elderly patients, the biological rather than the chronological age should be carefully assessed, and treatment should only be modified or withheld for very good reason. [9/04]

Management of Lung Cancer in Older Adults (American Cancer Society)
by Arti Hurria, MD, and Mark G. Kris, MD
v.53 CA Cancer J Clin (2003): 325-341
Comprehensive discussion of the management of lung cancer in older patients. Reviews the available data regarding surgery, radiation and systemic treatment for older patients and considers the role of geriatric assessment in the evaluation of older patients. Argues that age is not a significant prognostic factor for overall survival and response to treatment for patients with lung cancer. Aimed at health care professionals. See also the Editorial by Lodovico Balducci, MD, in the same issue: "Lung Cancer in the Elderly." [2003]

Chemotherapy in the Elderly NSCLC Patient

Chemotherapy Options for the Elderly Patient with Advanced NSCLC (The Oncologist)
by BT Hennessy, EO Hanrahan, OS Breathnach
v. 8, no.3 The Oncologist (June 2003): 270-277
Notes that subgroup analyses from large randomized Phase III trials suggest that elderly patients with good performance statuses do as well as younger patients treated with combination chemotherapy. Single agent vinorelbine (Navelbine) has been shown to have significant activity in elderly patients with NSCLC and to be well tolerated by those patients with good performance statuses, with associated improvements in measures of health. [6/03]

Chemotherapy & the Elderly NSCLC Patient - Recent MEDLINE Abstracts (PubMed)

Pharmacology of Chemotherapy in the Older Cancer Patient
by Lodovico Balducci, MD and Claudia Beghe, MD
v. 6, no.5 Cancer Control Journal (Sept./Oct. 1999)
Aimed at physicians, this article discusses individualized management of the older cancer patient within the context of a comprehensive geriatric assessment. Reviews factors that affect treatment decisions, including estimates of the extent of treatment toxicity, the impact of treatment on quality of life, estimates of life expectancy, and the influence of age on pharmacokinetic parameters. Stresses that treatment can be made safer and more effective in this population by adjusting chemotherapy dosage, maintaining hemoglobin levels, and using hemopoietic growth factors when appropriate. [10/99]

Radiation Therapy in the Elderly NSCLC Patient

Radiation Therapy & the Elderly NSCLC Patient - Recent MEDLINE Abstracts (PubMed)

High-dose Radiation Therapy for Elderly Patients with Inoperable or Unresectable NSCLC (PubMed)
Study results reported in the April 2001 issue of Lung Cancer indicate that definitive radiation therapy is recommended to the elderly aged 75 years or older with inoperable or unresectable NSCLC, especially early stage disease, as an acceptable choice of treatment. [4/01]

Curative Treatment by Radiation Therapy Alone of Stage 1 NSCLC in a Geriatric Population (PubMed)
Large retrospective review reported in the April 2001 issue of Lung Cancer concludes that radical radiation therapy with curative intent may be a viable alternative to surgery in those elderly patients who either refuse surgery or are judged to be unfit for operation. [4/01]

Surgery in the Elderly NSCLC Patient

Surgery & the Elderly NSCLC Patient - Recent MEDLINE Abstracts (PubMed)

Case Studies - Elderly NSCLC Patients

Therapeutic Options for an Elderly Woman with Metastatic NSCLC (Medscape)
Corey Langer, MD, recommends treatment options for a 74 year old female with a history of heavy smoking who presents with metastatic NSCLC. [4/04]



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Last modified: 27-Apr-2011
Karen Parles, MLS Editor