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Topics in SCLC Treatment

Prophylactic Cranial Irradiation

Palliative Brachytherapy

Radiation Sensitizers

Peripheral Blood Stem-Cell Transplantation

Prophylactic Cranial Irradiation

Prophylactic Cranial Irradiation in Small-Cell Lung Cancer (The Oncologist)
5, no.4 The Oncologist (August 2000): 293-298
Excellent comprehensive review of the literature on prophylactic cranial irradiation in SCLC patients. See also the commentary by Andrew T. Turrisi: "PCI in SCLC: Is It Still Controversial or Is It a No-Brainer?" in the same issue of The Oncologist. [8/00]

Prophylactic Cranial Irradiation (PCI) in SCLC (Cancer Care Ontario)
Aimed at physicians, this practice guideline addresses the question of the role of PCI in SCLC patients who have achieved complete response/remission. Discusses dose and fractionation schemes, and the effect of PCI on quality of life (scroll down to SCLC section). [11/03]

Cranial Irradiation for Preventing Brain Metastases of SCLC in Patients in Complete Remission (Cochrane Collaboration)
from Cochrane Review Abstracts
Examines available evidence from randomized trials to test whether prophylactic cranial irradiation (PCI) prolongs survival in SCLC patients in complete remission. Concludes that PCI significantly improves overall and disease-free survival for patients with SCLC in complete remission. Notes that further clinical trials are needed to confirm the potential greater benefit on brain metastasis rate suggested when PCI is given earlier or at higher doses. [2006]

PCI & SCLC - Recent MEDLINE Abstracts (PubMed)

PCI & SCLC - Clinical Trials (ClinicalTrials.gov)



Palliative Brachytherapy

High-Dose-Rate Brachytherapy (HDR-BT) Makes Palliative Radiation Effective, Convenient for Lung Cancer Patients (Doctor's Guide)
Discusses trial results reported at the 42nd Annual Meeting of the American Society for Therapeutic Radiology (ASTRO) that found high-dose-rate brachytherapy (HDR-BT) is an effective palliative therapy for central lung tumors, and that afterloading of the bronchus with two applications appears to be more effective and convenient for patients that is the standard four application dose. [10/00]



Radiation Sensitizers

Radiation Sensitizers - Recent MEDLINE Abstracts




 

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Last modified: 18-Feb-2009
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